With its chill vibe, ACME Hotel Chicago unites an artful eye for whimsical style and a penchant for high-tech toys for both work and play, making it the city's most approachable lifestyle hotel. Conde Nast 2021 Award Winner. Voted #10 for top hotels in the Chicago area. ACME is Located just off Michigan Avenue in the vibrant River North neighborhood of Chicago. Located just steps from the Magnificent Mile. ACME is all about self-expression and its tagline, DO YOUR THING is a celebration of guests' individuality. The vibrant lobby bar, The Berkshire Room, is an imaginative cocktail destination for locals, and the second floor Bodega offers a chill alternative with custom bottled drinks.