Welcome to the Holiday Inn Express & Suites in Hannibal, MO. We are conveniently located off Interstate 36 at the Shinn Lane exit making it a convenient choice for both business and leisure travelers. We are just walking distance from the Hannibal Regional Hospital, Hannibal Clinic, the James E Cary Cancer Center, and an array of dining options. The Holiday Inn Express & Suites is also in close proximity to the following major companies, BASF Corporation, Continental Cement, General Mills, Spartan LMP, and Watlow to name just a few. Hannibal's Historic Downtown is a short car ride away. Some of the local attractions are the Mark Twain Boyhood Home and Museums, the Mark Twain Cave, Mark Twain Riverboat, Hannibal Trolley Tours, Rockcliffe Mansion, and Haunted Hannibal Ghost Tours. Whether in town for business or pleasure, our hotel offers modern comfort with a feeling of home. Our nicely appointed rooms include high-speed wireless Internet, 42 inch flat screen TVs, microwaves and refrigerators. The hotel is also equipped with a business center, guest laundry, meeting space and deluxe suites are available. After your busy day, feel free to take a dip in the indoor heated pool or enjoy your workout in the fitness center. You can fill up at the Express Start Breakfast Bar with a delicious array of hot and cold favorites. Make your reservations to "Stay Smart" at our hotel. Call today and let us help you plan your next Midwest getaway! We look forward to your visit!