Experience Top-Rated Service at Our Florence, SC Hotel. Centrally located between Florida and New York in the heart of Florence, South Carolina, this hotel is at the intersection of I-95 and I-20 near the Florence Civic Center. The Holiday Inn Express®hotel in Florence is just a short drive from Charleston, Columbia, Myrtle Beach, Charlotte or Raleigh. Those on business trips to Florence, South Carolina benefit from the hotel's proximity to General Electric, Honda, McLeod Medical Center, Sara Lee, ACS Technologies, Francis Marion University, State Farm Insurance and QVC. We can also help you get work completed thanks to our on-site business center and complimentary high-speed, wireless Internet access. Travelers adore the convenience of our Florence, SC hotel as great restaurants like Outback Steakhouse, Olive Garden, Longhorn Steakhouse and Chili's are right at our doorstep. You'll find great shopping at Magnolia Mall. Looking for more involved distractions? We're next to the Swampfox Cinema and Florence Civic Center. The Darlington Raceway, NASCAR Hall of Fame and War Between the States Museum are nearby, as well. This modern Florence, SC hotel has great on-site amenities, too, like an indoor saline pool and whirlpool as well as a great cardio fitness center. Best of all, each day begins with a free Express Start Breakfast, featuring the best hot cinnamon rolls you have ever tasted.