Welcome to the Best Hotel in Beaufort, SC You'll discover Southern hospitality and charm at the Holiday Inn Beaufort, nestled in the heart of South Carolina's Lowcountry. Our location is just off Highway 170 and Route 21 and overlooks the Beaufort River in Beaufort, SC, an antebellum seaside town that is steeped in history and beauty. Our hotel in Beaufort, SC welcomes family and friends attending the year-round graduation ceremonies at the Parris Island Marine Recruitment Center, six miles from our hotel. Beaufort's downtown is rich in history and just one mile away. You can take a horse-drawn buggy tour with a guide to discover the secrets of historic Beaufort. And it's easy to spend a day on the inter-coastal waterway or island hop to Hilton Head, as it is just a half-hour away. Corporate guests love that our Beaufort hotel is near Parris Island. The University of South Carolina - Beaufort is two miles & Beaufort Memorial Hospital is just minutes away Guests can relax by the indoor pool and spa or enjoy a workout in the Fitness Center. A 24-hour Business Center allows you to catch up on work or check your email. Planning a wedding or event? We have over 5,400 sq. ft, of space, as well as full in house catering. Don't forget to stop by Albergotti's Grill inside the main lobby to enjoy a local, lowcountry menu. The Holiday Inn Beaufort welcomes you with top-notch service, Southern hospitality and an award-winning attitude.