Our Hampton Inn Opelousas hotel features a new and upscale design and is located near many things to do in Louisiana's third oldest city near the Atchafalaya River. We are located off Interstate 49 within 5 miles of the Wal-Mart Distribution Center, a top employer in this historic area filled with music, authentic cuisine and beautiful architecture. After a busy day, relax in one of our spacious rooms or suites on a clean and fresh Hampton bed®. Rooms have a 42-inch HDTV with premium channels for watching your favorite shows and a large work desk with ergonomic chair for getting work done. Upgrade for a room with more space and a sofa bed. With free hot breakfast daily, start your day on the right foot. Even if you're in a hurry, you have time to grab Hampton's On the Run Breakfast Bags, available Monday through Friday. Ask our friendly team for lunch and dinner options in Opelousas. Spend time at the outdoor seasonal pool and get in a complete workout in our fitness center. Our hotel offers easy access to many top Opelousas, LA meeting spaces, free self-parking and free remote printing so you'll get the most out of your stay with us.