Home2 Suites by Hilton Rochester Mayo Clinic Area is ideally located off of U. S. 52 and U. S. 63, within minutes of the world famous Mayo Clinic, Saint Marys Hospital, Rochester International Airport, Plummer House, Mayo Civic Center, and Graham Arena. Here to play? Our hotel is connected to the scenic Zumbro River Trail system, offering access to 80 miles of paved biking and walking trails; and our staff can recommend the area's best spots for biking, golfing, fishing and hiking. We're also just steps away from the Apache Mall, south-eastern Minnesota's premier shopping destination. Enjoy the convenience of our neighboring restaurants which include Panera Bread and Hot Chip Burger Bar within walking distance to our property. Whether you're here for a short-term or extended stay we're perfectly suited to accommodate your needs.