A Newly Renovated Hotel in Hyannis, Cape Cod! Stylish and contemporary, our Holiday Inn® Cape Cod Hyannis Hotel is conveniently located in the center of Cape Cod, and offers easy access to breathtaking beaches, historic charm, fine dining, and entertainment. While in the area, visit one of the many attractions including the JFK Museum, vibrant Main Street, the Hyannis waterfront district, and a myriad of beaches. While staying in Hyannis Cape Cod, hotel guests can enjoy taking a short ferry ride to Martha's Vineyard and Nantucket or a day trip to Provincetown and the National Seashore. World class whalewatching awaits courtesy of Hyannis Whale Watcher Cruises departing from nearby Barnstable Harbor. Just minutes from the Barnstable Municipal Airport, our hotel's address on Iyannough Road is close to the Independence Park Business area - home to a number of local companies including Cape Cod Healthcare. We're also minutes from the Cape Cod Hospital, Hyannis Youth and Community Center and 21. 9 miles from Joint Base Cape Cod. With our 24-hour Business Center and six spacious meeting rooms, we cover all of your corporate needs. Enjoy our many amenities including our well equipped Fitness Center, heated indoor pool and whirlpool and seasonal outdoor pool. Start your day off right with a delicious breakfast in our Restaurant and later enjoy dinner and drinks at the Mad Hatter lounge. Make the smart choice and stay at the Holiday Inn Hyannis.